diff --git a/src/core/fullscreen_ui.cpp b/src/core/fullscreen_ui.cpp
index e287f68cd..571da9924 100644
--- a/src/core/fullscreen_ui.cpp
+++ b/src/core/fullscreen_ui.cpp
@@ -272,8 +272,9 @@ static void DoStartBIOS();
 static void DoStartDisc(std::string path);
 static void DoStartDisc();
 static void DoToggleFastForward();
-static void DoShutdown(bool save_state);
-static void DoReset();
+static void ConfirmIfSavingMemoryCards(std::string_view action, std::function<void(bool)> callback);
+static void RequestShutdown(bool save_state);
+static void RequestReset();
 static void DoChangeDiscFromFile();
 static void DoChangeDisc();
 static void DoRequestExit();
@@ -1026,14 +1027,44 @@ void FullscreenUI::DoStartDisc()
                    });
 }
 
-void FullscreenUI::DoShutdown(bool save_state)
+void FullscreenUI::ConfirmIfSavingMemoryCards(std::string_view action, std::function<void(bool)> callback)
 {
-  Host::RunOnCPUThread([save_state]() { Host::RequestSystemShutdown(false, save_state); });
+  if (!System::IsSavingMemoryCards())
+  {
+    callback(true);
+    return;
+  }
+
+  OpenConfirmMessageDialog(
+    FSUI_ICONSTR(ICON_PF_MEMORY_CARD, "Memory Card Busy"),
+    fmt::format(FSUI_FSTR("WARNING: Your game is still saving to the memory card. Continuing to {0} may IRREVERSIBLY "
+                          "DESTROY YOUR MEMORY CARD. We recommend resuming your game and waiting 5 seconds for it to "
+                          "finish saving.\n\nDo you want to {0} anyway?"),
+                action),
+    std::move(callback),
+    fmt::format(
+      fmt::runtime(FSUI_ICONSTR(ICON_FA_EXCLAMATION_TRIANGLE, "Yes, {} now and risk memory card corruption.")), action),
+    FSUI_ICONSTR(ICON_FA_PLAY, "No, resume the game."));
 }
 
-void FullscreenUI::DoReset()
+void FullscreenUI::RequestShutdown(bool save_state)
 {
-  Host::RunOnCPUThread(System::ResetSystem);
+  ConfirmIfSavingMemoryCards(FSUI_VSTR("shut down"), [save_state](bool result) {
+    if (result)
+      Host::RunOnCPUThread([save_state]() { Host::RequestSystemShutdown(false, save_state); });
+    else
+      ClosePauseMenu();
+  });
+}
+
+void FullscreenUI::RequestReset()
+{
+  ConfirmIfSavingMemoryCards(FSUI_VSTR("reset"), [](bool result) {
+    if (result)
+      Host::RunOnCPUThread(System::ResetSystem);
+    else
+      ClosePauseMenu();
+  });
 }
 
 void FullscreenUI::DoToggleFastForward()
@@ -1048,27 +1079,35 @@ void FullscreenUI::DoToggleFastForward()
 
 void FullscreenUI::DoChangeDiscFromFile()
 {
-  auto callback = [](const std::string& path) {
-    if (!path.empty())
+  ConfirmIfSavingMemoryCards(FSUI_VSTR("change disc"), [](bool result) {
+    if (!result)
     {
-      if (!GameList::IsScannableFilename(path))
-      {
-        ShowToast({},
-                  fmt::format(FSUI_FSTR("{} is not a valid disc image."), FileSystem::GetDisplayNameFromPath(path)));
-      }
-      else
-      {
-        Host::RunOnCPUThread([path]() { System::InsertMedia(path.c_str()); });
-      }
+      ClosePauseMenu();
+      return;
     }
 
-    QueueResetFocus();
-    CloseFileSelector();
-    ReturnToPreviousWindow();
-  };
+    auto callback = [](const std::string& path) {
+      if (!path.empty())
+      {
+        if (!GameList::IsScannableFilename(path))
+        {
+          ShowToast({},
+                    fmt::format(FSUI_FSTR("{} is not a valid disc image."), FileSystem::GetDisplayNameFromPath(path)));
+        }
+        else
+        {
+          Host::RunOnCPUThread([path]() { System::InsertMedia(path.c_str()); });
+        }
+      }
 
-  OpenFileSelector(FSUI_ICONSTR(ICON_FA_COMPACT_DISC, "Select Disc Image"), false, std::move(callback),
-                   GetDiscImageFilters(), std::string(Path::GetDirectory(System::GetDiscPath())));
+      QueueResetFocus();
+      CloseFileSelector();
+      ReturnToPreviousWindow();
+    };
+
+    OpenFileSelector(FSUI_ICONSTR(ICON_FA_COMPACT_DISC, "Select Disc Image"), false, std::move(callback),
+                     GetDiscImageFilters(), std::string(Path::GetDirectory(System::GetDiscPath())));
+  });
 }
 
 void FullscreenUI::DoChangeDisc()
@@ -5277,7 +5316,7 @@ void FullscreenUI::DrawPauseMenu()
         {
           // skip submenu when we can't save anyway
           if (!has_game)
-            DoShutdown(false);
+            RequestShutdown(false);
           else
             OpenPauseSubMenu(PauseSubMenu::Exit);
         }
@@ -5298,14 +5337,14 @@ void FullscreenUI::DrawPauseMenu()
         if (ActiveButton(FSUI_ICONSTR(ICON_FA_SYNC, "Reset System"), false))
         {
           ClosePauseMenu();
-          DoReset();
+          RequestReset();
         }
 
         if (ActiveButton(FSUI_ICONSTR(ICON_FA_SAVE, "Exit And Save State"), false))
-          DoShutdown(true);
+          RequestShutdown(true);
 
         if (ActiveButton(FSUI_ICONSTR(ICON_FA_POWER_OFF, "Exit Without Saving"), false))
-          DoShutdown(false);
+          RequestShutdown(false);
       }
       break;
 
diff --git a/src/core/memory_card.cpp b/src/core/memory_card.cpp
index 76e5dda94..da04d8511 100644
--- a/src/core/memory_card.cpp
+++ b/src/core/memory_card.cpp
@@ -270,6 +270,11 @@ bool MemoryCard::Transfer(const u8 data_in, u8* data_out)
   return ack;
 }
 
+bool MemoryCard::IsOrWasRecentlyWriting() const
+{
+  return (m_state == State::WriteData || m_save_event->IsActive());
+}
+
 std::unique_ptr<MemoryCard> MemoryCard::Create()
 {
   std::unique_ptr<MemoryCard> mc = std::make_unique<MemoryCard>();
diff --git a/src/core/memory_card.h b/src/core/memory_card.h
index aef10d6d0..314547645 100644
--- a/src/core/memory_card.h
+++ b/src/core/memory_card.h
@@ -35,6 +35,8 @@ public:
   void ResetTransferState();
   bool Transfer(const u8 data_in, u8* data_out);
 
+  bool IsOrWasRecentlyWriting() const;
+
   void Format();
 
 private:
diff --git a/src/core/system.cpp b/src/core/system.cpp
index d49c375a3..94f4e709c 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -3300,6 +3300,18 @@ bool System::HasMemoryCard(u32 slot)
   return (Pad::GetMemoryCard(slot) != nullptr);
 }
 
+bool System::IsSavingMemoryCards()
+{
+  for (u32 i = 0; i < NUM_CONTROLLER_AND_CARD_PORTS; i++)
+  {
+    MemoryCard* card = Pad::GetMemoryCard(i);
+    if (card && card->IsOrWasRecentlyWriting())
+      return true;
+  }
+
+  return false;
+}
+
 void System::SwapMemoryCards()
 {
   if (!IsValid())
diff --git a/src/core/system.h b/src/core/system.h
index cc6926cc1..bd735444a 100644
--- a/src/core/system.h
+++ b/src/core/system.h
@@ -301,6 +301,7 @@ void ResetControllers();
 void UpdateMemoryCardTypes();
 void UpdatePerGameMemoryCards();
 bool HasMemoryCard(u32 slot);
+bool IsSavingMemoryCards();
 
 /// Swaps memory cards in slot 1/2.
 void SwapMemoryCards();
diff --git a/src/duckstation-qt/achievementlogindialog.cpp b/src/duckstation-qt/achievementlogindialog.cpp
index 1f1413957..f79b4234d 100644
--- a/src/duckstation-qt/achievementlogindialog.cpp
+++ b/src/duckstation-qt/achievementlogindialog.cpp
@@ -110,7 +110,7 @@ void AchievementLoginDialog::processLoginResult(bool result, const QString& mess
           tr("Hardcore mode will not be enabled until the system is reset. Do you want to reset the system now?")) ==
           QMessageBox::Yes)
     {
-      g_emu_thread->resetSystem();
+      g_emu_thread->resetSystem(true);
     }
   }
 
diff --git a/src/duckstation-qt/achievementsettingswidget.cpp b/src/duckstation-qt/achievementsettingswidget.cpp
index d24dc221f..b4a75c93d 100644
--- a/src/duckstation-qt/achievementsettingswidget.cpp
+++ b/src/duckstation-qt/achievementsettingswidget.cpp
@@ -154,7 +154,7 @@ void AchievementSettingsWidget::onHardcoreModeStateChanged()
     return;
   }
 
-  g_emu_thread->resetSystem();
+  g_emu_thread->resetSystem(true);
 }
 
 void AchievementSettingsWidget::onAchievementsNotificationDurationSliderChanged()
diff --git a/src/duckstation-qt/mainwindow.cpp b/src/duckstation-qt/mainwindow.cpp
index 9f8bd6413..588664f9c 100644
--- a/src/duckstation-qt/mainwindow.cpp
+++ b/src/duckstation-qt/mainwindow.cpp
@@ -700,7 +700,7 @@ void MainWindow::quit()
   // Make sure VM is gone. It really should be if we're here.
   if (s_system_valid)
   {
-    g_emu_thread->shutdownSystem(false);
+    g_emu_thread->shutdownSystem(false, true);
     while (s_system_valid)
       QApplication::processEvents(QEventLoop::ExcludeUserInputEvents, 1);
   }
@@ -990,7 +990,7 @@ void MainWindow::populateChangeDiscSubImageMenu(QMenu* menu, QActionGroup* actio
       QString path = QString::fromStdString(glentry->path);
       action->setCheckable(true);
       action->setChecked(path == s_current_game_path);
-      connect(action, &QAction::triggered, [path = std::move(path)]() { g_emu_thread->changeDisc(path); });
+      connect(action, &QAction::triggered, [path = std::move(path)]() { g_emu_thread->changeDisc(path, false, true); });
       menu->addAction(action);
     }
   }
@@ -1232,9 +1232,7 @@ void MainWindow::promptForDiscChange(const QString& path)
 
   switchToEmulationView();
 
-  g_emu_thread->changeDisc(path);
-  if (reset_system)
-    g_emu_thread->resetSystem();
+  g_emu_thread->changeDisc(path, reset_system, true);
 }
 
 void MainWindow::onStartDiscActionTriggered()
@@ -1258,7 +1256,7 @@ void MainWindow::onChangeDiscFromFileActionTriggered()
   if (filename.isEmpty())
     return;
 
-  g_emu_thread->changeDisc(filename);
+  g_emu_thread->changeDisc(filename, false, true);
 }
 
 void MainWindow::onChangeDiscFromGameListActionTriggered()
@@ -1273,7 +1271,7 @@ void MainWindow::onChangeDiscFromDeviceActionTriggered()
   if (path.empty())
     return;
 
-  g_emu_thread->changeDisc(QString::fromStdString(path));
+  g_emu_thread->changeDisc(QString::fromStdString(path), false, true);
 }
 
 void MainWindow::onChangeDiscMenuAboutToShow()
@@ -1317,7 +1315,7 @@ void MainWindow::onFullscreenUIStateChange(bool running)
 
 void MainWindow::onRemoveDiscActionTriggered()
 {
-  g_emu_thread->changeDisc(QString());
+  g_emu_thread->changeDisc(QString(), false, true);
 }
 
 void MainWindow::onViewToolbarActionToggled(bool checked)
@@ -1511,7 +1509,7 @@ void MainWindow::onGameListEntryContextMenuRequested(const QPoint& point)
     else
     {
       connect(menu.addAction(tr("Change Disc")), &QAction::triggered, [this, entry]() {
-        g_emu_thread->changeDisc(QString::fromStdString(entry->path));
+        g_emu_thread->changeDisc(QString::fromStdString(entry->path), false, true);
         g_emu_thread->setSystemPaused(false);
         switchToEmulationView();
       });
@@ -2031,8 +2029,8 @@ void MainWindow::connectSignals()
           [this]() { requestShutdown(true, true, g_settings.save_state_on_exit); });
   connect(m_ui.actionPowerOffWithoutSaving, &QAction::triggered, this,
           [this]() { requestShutdown(false, false, false); });
-  connect(m_ui.actionReset, &QAction::triggered, g_emu_thread, &EmuThread::resetSystem);
-  connect(m_ui.actionPause, &QAction::toggled, [](bool active) { g_emu_thread->setSystemPaused(active); });
+  connect(m_ui.actionReset, &QAction::triggered, this, []() { g_emu_thread->resetSystem(true); });
+  connect(m_ui.actionPause, &QAction::toggled, this, [](bool active) { g_emu_thread->setSystemPaused(active); });
   connect(m_ui.actionScreenshot, &QAction::triggered, g_emu_thread, &EmuThread::saveScreenshot);
   connect(m_ui.actionScanForNewGames, &QAction::triggered, this, [this]() { refreshGameList(false); });
   connect(m_ui.actionRescanAllGames, &QAction::triggered, this, [this]() { refreshGameList(true); });
@@ -2862,7 +2860,7 @@ bool MainWindow::requestShutdown(bool allow_confirm /* = true */, bool allow_sav
     updateWindowState(true);
 
   // Now we can actually shut down the VM.
-  g_emu_thread->shutdownSystem(save_state);
+  g_emu_thread->shutdownSystem(save_state, true);
   return true;
 }
 
diff --git a/src/duckstation-qt/qthost.cpp b/src/duckstation-qt/qthost.cpp
index 9e57fa0b5..299c4acca 100644
--- a/src/duckstation-qt/qthost.cpp
+++ b/src/duckstation-qt/qthost.cpp
@@ -1067,23 +1067,72 @@ void EmuThread::enumerateVibrationMotors()
   onVibrationMotorsEnumerated(qmotors);
 }
 
-void EmuThread::shutdownSystem(bool save_state /* = true */)
+void EmuThread::confirmActionIfMemoryCardBusy(const QString& action, bool cancel_resume_on_accept,
+                                              std::function<void(bool)> callback) const
+{
+  DebugAssert(isOnThread());
+
+  if (!System::IsValid() || !System::IsSavingMemoryCards())
+  {
+    callback(true);
+    return;
+  }
+
+  QtHost::RunOnUIThread([action, cancel_resume_on_accept, callback = std::move(callback)]() mutable {
+    auto lock = g_main_window->pauseAndLockSystem();
+
+    const bool result =
+      (QMessageBox::question(lock.getDialogParent(), tr("Memory Card Busy"),
+                             tr("WARNING: Your game is still saving to the memory card. Continuing to %1 may "
+                                "IRREVERSIBLY DESTROY YOUR MEMORY CARD. We recommend resuming your game and waiting 5 "
+                                "seconds for it to finish saving.\n\nDo you want to %1 anyway?")
+                               .arg(action)) != QMessageBox::No);
+
+    if (cancel_resume_on_accept)
+      lock.cancelResume();
+
+    Host::RunOnCPUThread([result, callback = std::move(callback)]() { callback(result); });
+  });
+}
+
+void EmuThread::shutdownSystem(bool save_state, bool check_memcard_busy)
 {
   if (!isOnThread())
   {
     System::CancelPendingStartup();
-    QMetaObject::invokeMethod(this, "shutdownSystem", Qt::QueuedConnection, Q_ARG(bool, save_state));
+    QMetaObject::invokeMethod(this, "shutdownSystem", Qt::QueuedConnection, Q_ARG(bool, save_state),
+                              Q_ARG(bool, check_memcard_busy));
+    return;
+  }
+
+  if (check_memcard_busy && System::IsSavingMemoryCards())
+  {
+    confirmActionIfMemoryCardBusy(tr("shut down"), true, [save_state](bool result) {
+      if (result)
+        g_emu_thread->shutdownSystem(save_state, false);
+      else
+        g_emu_thread->setSystemPaused(false);
+    });
     return;
   }
 
   System::ShutdownSystem(save_state);
 }
 
-void EmuThread::resetSystem()
+void EmuThread::resetSystem(bool check_memcard_busy)
 {
   if (!isOnThread())
   {
-    QMetaObject::invokeMethod(this, &EmuThread::resetSystem, Qt::QueuedConnection);
+    QMetaObject::invokeMethod(this, "resetSystem", Qt::QueuedConnection, Q_ARG(bool, check_memcard_busy));
+    return;
+  }
+
+  if (check_memcard_busy && System::IsSavingMemoryCards())
+  {
+    confirmActionIfMemoryCardBusy(tr("reset"), false, [](bool result) {
+      if (result)
+        g_emu_thread->resetSystem(false);
+    });
     return;
   }
 
@@ -1103,11 +1152,21 @@ void EmuThread::setSystemPaused(bool paused, bool wait_until_paused /* = false *
   System::PauseSystem(paused);
 }
 
-void EmuThread::changeDisc(const QString& new_disc_filename)
+void EmuThread::changeDisc(const QString& new_disc_filename, bool reset_system, bool check_memcard_busy)
 {
   if (!isOnThread())
   {
-    QMetaObject::invokeMethod(this, "changeDisc", Qt::QueuedConnection, Q_ARG(const QString&, new_disc_filename));
+    QMetaObject::invokeMethod(this, "changeDisc", Qt::QueuedConnection, Q_ARG(const QString&, new_disc_filename),
+                              Q_ARG(bool, reset_system), Q_ARG(bool, check_memcard_busy));
+    return;
+  }
+
+  if (check_memcard_busy && System::IsSavingMemoryCards())
+  {
+    confirmActionIfMemoryCardBusy(tr("change disc"), false, [new_disc_filename, reset_system](bool result) {
+      if (result)
+        g_emu_thread->changeDisc(new_disc_filename, reset_system, false);
+    });
     return;
   }
 
@@ -1118,6 +1177,9 @@ void EmuThread::changeDisc(const QString& new_disc_filename)
     System::InsertMedia(new_disc_filename.toStdString().c_str());
   else
     System::RemoveMedia();
+
+  if (reset_system)
+    System::ResetSystem();
 }
 
 void EmuThread::changeDiscFromPlaylist(quint32 index)
diff --git a/src/duckstation-qt/qthost.h b/src/duckstation-qt/qthost.h
index 4f0aee4b6..d10abc3ef 100644
--- a/src/duckstation-qt/qthost.h
+++ b/src/duckstation-qt/qthost.h
@@ -168,10 +168,10 @@ public Q_SLOTS:
   void stopFullscreenUI();
   void bootSystem(std::shared_ptr<SystemBootParameters> params);
   void resumeSystemFromMostRecentState();
-  void shutdownSystem(bool save_state = true);
-  void resetSystem();
+  void shutdownSystem(bool save_state, bool check_memcard_busy);
+  void resetSystem(bool check_memcard_busy);
   void setSystemPaused(bool paused, bool wait_until_paused = false);
-  void changeDisc(const QString& new_disc_filename);
+  void changeDisc(const QString& new_disc_filename, bool reset_system, bool check_memcard_busy);
   void changeDiscFromPlaylist(quint32 index);
   void loadState(const QString& filename);
   void loadState(bool global, qint32 slot);
@@ -218,6 +218,8 @@ private:
   void createBackgroundControllerPollTimer();
   void destroyBackgroundControllerPollTimer();
   void setInitialState(std::optional<bool> override_fullscreen);
+  void confirmActionIfMemoryCardBusy(const QString& action, bool cancel_resume_on_accept,
+                                     std::function<void(bool)> callback) const;
 
   QThread* m_ui_thread;
   QSemaphore m_started_semaphore;