diff --git a/android/app/src/main/res/values/strings.xml b/android/app/src/main/res/values/strings.xml
index f381af3c0..f0aac9365 100644
--- a/android/app/src/main/res/values/strings.xml
+++ b/android/app/src/main/res/values/strings.xml
@@ -180,4 +180,6 @@
     <string name="settings_use_analog_sticks_for_dpad">Use Analog Sticks for D-Pad in Digital Mode</string>
     <string name="settings_summary_enable_analog_mode_on_reset">Forces the controller to analog mode when the console is reset/powered on.</string>
     <string name="settings_summary_use_analog_sticks_for_dpad">Allows you to use the analog sticks to control the d-pad in digital mode, as well as the buttons.</string>
+    <string name="settings_disable_all_enhancements">Disable All Enhancements</string>
+    <string name="settings_summary_disable_all_enhancements">Temporarily disables all enhancements, which can be useful when debugging issues.</string>
 </resources>
diff --git a/android/app/src/main/res/xml/advanced_preferences.xml b/android/app/src/main/res/xml/advanced_preferences.xml
index ad5fd714b..c392f9219 100644
--- a/android/app/src/main/res/xml/advanced_preferences.xml
+++ b/android/app/src/main/res/xml/advanced_preferences.xml
@@ -23,6 +23,12 @@
         app:entryValues="@array/settings_language_values"
         app:useSimpleSummaryProvider="true"
         app:iconSpaceReserved="false" />
+    <SwitchPreferenceCompat
+        app:key="Main/DisableAllEnhancements"
+        app:title="@string/settings_disable_all_enhancements"
+        app:defaultValue="false"
+        app:summary="@string/settings_summary_disable_all_enhancements"
+        app:iconSpaceReserved="false" />
     <ListPreference
         app:key="CPU/Overclock"
         app:title="@string/settings_cpu_overclocking"
diff --git a/src/core/host_interface.cpp b/src/core/host_interface.cpp
index c946bbdd7..cd8490cb8 100644
--- a/src/core/host_interface.cpp
+++ b/src/core/host_interface.cpp
@@ -462,6 +462,7 @@ void HostInterface::SetDefaultSettings(SettingsInterface& si)
   si.SetBoolValue("Main", "ConfirmPowerOff", true);
   si.SetBoolValue("Main", "LoadDevicesFromSaveStates", false);
   si.SetBoolValue("Main", "ApplyGameSettings", true);
+  si.SetBoolValue("Main", "DisableAllEnhancements", false);
 
   si.SetStringValue("CPU", "ExecutionMode", Settings::GetCPUExecutionModeName(Settings::DEFAULT_CPU_EXECUTION_MODE));
   si.SetBoolValue("CPU", "RecompilerMemoryExceptions", false);
@@ -573,6 +574,28 @@ void HostInterface::LoadSettings(SettingsInterface& si)
 
 void HostInterface::FixIncompatibleSettings(bool display_osd_messages)
 {
+  if (g_settings.disable_all_enhancements)
+  {
+    g_settings.cpu_overclock_enable = false;
+    g_settings.cpu_overclock_active = false;
+    g_settings.gpu_resolution_scale = 1;
+    g_settings.gpu_multisamples = 1;
+    g_settings.gpu_per_sample_shading = false;
+    g_settings.gpu_true_color = false;
+    g_settings.gpu_scaled_dithering = false;
+    g_settings.gpu_texture_filter = GPUTextureFilter::Nearest;
+    g_settings.gpu_disable_interlacing = false;
+    g_settings.gpu_force_ntsc_timings = false;
+    g_settings.gpu_widescreen_hack = false;
+    g_settings.gpu_pgxp_enable = false;
+    g_settings.gpu_24bit_chroma_smoothing = false;
+    g_settings.cdrom_read_speedup = false;
+    g_settings.cdrom_mute_cd_audio = false;
+    g_settings.texture_replacements.enable_vram_write_replacements = false;
+    g_settings.bios_patch_fast_boot = false;
+    g_settings.bios_patch_tty_enable = false;
+  }
+
   if (g_settings.gpu_pgxp_enable)
   {
     if (g_settings.gpu_renderer == GPURenderer::Software)
diff --git a/src/core/settings.cpp b/src/core/settings.cpp
index 211a8a717..af8f8f863 100644
--- a/src/core/settings.cpp
+++ b/src/core/settings.cpp
@@ -120,6 +120,7 @@ void Settings::Load(SettingsInterface& si)
   load_devices_from_save_states = si.GetBoolValue("Main", "LoadDevicesFromSaveStates", false);
   apply_game_settings = si.GetBoolValue("Main", "ApplyGameSettings", true);
   auto_load_cheats = si.GetBoolValue("Main", "AutoLoadCheats", false);
+  disable_all_enhancements = si.GetBoolValue("Main", "DisableAllEnhancements", false);
 
   cpu_execution_mode =
     ParseCPUExecutionMode(
@@ -284,6 +285,7 @@ void Settings::Save(SettingsInterface& si) const
   si.SetBoolValue("Main", "LoadDevicesFromSaveStates", load_devices_from_save_states);
   si.SetBoolValue("Main", "ApplyGameSettings", apply_game_settings);
   si.SetBoolValue("Main", "AutoLoadCheats", auto_load_cheats);
+  si.SetBoolValue("Main", "DisableAllEnhancements", disable_all_enhancements);
 
   si.SetStringValue("CPU", "ExecutionMode", GetCPUExecutionModeName(cpu_execution_mode));
   si.SetBoolValue("CPU", "OverclockEnable", cpu_overclock_enable);
diff --git a/src/core/settings.h b/src/core/settings.h
index a4b929bba..060a68cec 100644
--- a/src/core/settings.h
+++ b/src/core/settings.h
@@ -90,6 +90,7 @@ struct Settings
   bool load_devices_from_save_states = false;
   bool apply_game_settings = true;
   bool auto_load_cheats = false;
+  bool disable_all_enhancements = false;
 
   GPURenderer gpu_renderer = GPURenderer::Software;
   std::string gpu_adapter;
diff --git a/src/duckstation-qt/advancedsettingswidget.cpp b/src/duckstation-qt/advancedsettingswidget.cpp
index 230d6762d..b9a327e32 100644
--- a/src/duckstation-qt/advancedsettingswidget.cpp
+++ b/src/duckstation-qt/advancedsettingswidget.cpp
@@ -145,6 +145,8 @@ AdvancedSettingsWidget::AdvancedSettingsWidget(QtHostInterface* host_interface,
 
   m_ui.tweakOptionTable->setColumnWidth(0, 380);
 
+  addBooleanTweakOption(m_host_interface, m_ui.tweakOptionTable, tr("Disable All Enhancements"), "Main",
+                        "DisableAllEnhancements", false);
   addIntRangeTweakOption(m_host_interface, m_ui.tweakOptionTable, tr("Display FPS Limit"), "Display", "MaxFPS", 0, 1000,
                          0);
 
@@ -201,25 +203,26 @@ AdvancedSettingsWidget::~AdvancedSettingsWidget() = default;
 
 void AdvancedSettingsWidget::onResetToDefaultClicked()
 {
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 0, 0);
-  setBooleanTweakOption(m_ui.tweakOptionTable, 1, false);
+  setBooleanTweakOption(m_ui.tweakOptionTable, 0, false);
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 1, 0);
   setBooleanTweakOption(m_ui.tweakOptionTable, 2, false);
   setBooleanTweakOption(m_ui.tweakOptionTable, 3, false);
-  setFloatRangeTweakOption(m_ui.tweakOptionTable, 4, -1.0f);
-  setFloatRangeTweakOption(m_ui.tweakOptionTable, 5, Settings::DEFAULT_GPU_PGXP_DEPTH_THRESHOLD);
-  setBooleanTweakOption(m_ui.tweakOptionTable, 6, false);
-  setChoiceTweakOption(m_ui.tweakOptionTable, 7, Settings::DEFAULT_CPU_FASTMEM_MODE);
-  setBooleanTweakOption(m_ui.tweakOptionTable, 8, false);
+  setBooleanTweakOption(m_ui.tweakOptionTable, 4, false);
+  setFloatRangeTweakOption(m_ui.tweakOptionTable, 5, -1.0f);
+  setFloatRangeTweakOption(m_ui.tweakOptionTable, 6, Settings::DEFAULT_GPU_PGXP_DEPTH_THRESHOLD);
+  setBooleanTweakOption(m_ui.tweakOptionTable, 7, false);
+  setChoiceTweakOption(m_ui.tweakOptionTable, 8, Settings::DEFAULT_CPU_FASTMEM_MODE);
   setBooleanTweakOption(m_ui.tweakOptionTable, 9, false);
   setBooleanTweakOption(m_ui.tweakOptionTable, 10, false);
   setBooleanTweakOption(m_ui.tweakOptionTable, 11, false);
   setBooleanTweakOption(m_ui.tweakOptionTable, 12, false);
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 13, Settings::DEFAULT_VRAM_WRITE_DUMP_WIDTH_THRESHOLD);
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 14, Settings::DEFAULT_VRAM_WRITE_DUMP_HEIGHT_THRESHOLD);
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 15, static_cast<int>(Settings::DEFAULT_DMA_MAX_SLICE_TICKS));
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 16, static_cast<int>(Settings::DEFAULT_DMA_HALT_TICKS));
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 17, static_cast<int>(Settings::DEFAULT_GPU_FIFO_SIZE));
-  setIntRangeTweakOption(m_ui.tweakOptionTable, 18, static_cast<int>(Settings::DEFAULT_GPU_MAX_RUN_AHEAD));
-  setBooleanTweakOption(m_ui.tweakOptionTable, 19, false);
-  setBooleanTweakOption(m_ui.tweakOptionTable, 20, true);
+  setBooleanTweakOption(m_ui.tweakOptionTable, 13, false);
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 14, Settings::DEFAULT_VRAM_WRITE_DUMP_WIDTH_THRESHOLD);
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 15, Settings::DEFAULT_VRAM_WRITE_DUMP_HEIGHT_THRESHOLD);
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 16, static_cast<int>(Settings::DEFAULT_DMA_MAX_SLICE_TICKS));
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 17, static_cast<int>(Settings::DEFAULT_DMA_HALT_TICKS));
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 18, static_cast<int>(Settings::DEFAULT_GPU_FIFO_SIZE));
+  setIntRangeTweakOption(m_ui.tweakOptionTable, 19, static_cast<int>(Settings::DEFAULT_GPU_MAX_RUN_AHEAD));
+  setBooleanTweakOption(m_ui.tweakOptionTable, 20, false);
+  setBooleanTweakOption(m_ui.tweakOptionTable, 21, true);
 }
diff --git a/src/duckstation-sdl/sdl_host_interface.cpp b/src/duckstation-sdl/sdl_host_interface.cpp
index cce2ad925..b0d0b3feb 100644
--- a/src/duckstation-sdl/sdl_host_interface.cpp
+++ b/src/duckstation-sdl/sdl_host_interface.cpp
@@ -1156,6 +1156,7 @@ void SDLHostInterface::DrawDebugMenu()
 
   ImGui::Separator();
 
+  settings_changed |= ImGui::MenuItem("Disable All Enhancements", nullptr, &m_settings_copy.disable_all_enhancements);
   settings_changed |= ImGui::MenuItem("Dump CPU to VRAM Copies", nullptr, &debug_settings.dump_cpu_to_vram_copies);
   settings_changed |= ImGui::MenuItem("Dump VRAM to CPU Copies", nullptr, &debug_settings.dump_vram_to_cpu_copies);