diff --git a/src/duckstation-qt/mainwindow.cpp b/src/duckstation-qt/mainwindow.cpp
index 7d3bdc5d3..54ceb246a 100644
--- a/src/duckstation-qt/mainwindow.cpp
+++ b/src/duckstation-qt/mainwindow.cpp
@@ -1505,6 +1505,22 @@ void MainWindow::onCheckForUpdatesActionTriggered()
 
 void MainWindow::openMemoryCardEditor(const QString& card_a_path, const QString& card_b_path)
 {
+  for (const QString& card_path : {card_a_path, card_b_path})
+  {
+    if (!card_path.isEmpty() && !QFile::exists(card_path))
+    {
+      if (QMessageBox::question(
+            this, tr("Memory Card Not Found"),
+            tr("Memory card '%1' does not exist. Do you want to create an empty memory card?").arg(card_path),
+            QMessageBox::Yes, QMessageBox::No) == QMessageBox::Yes)
+      {
+        if (!MemoryCardEditorDialog::createMemoryCard(card_path))
+          QMessageBox::critical(this, tr("Memory Card Not Found"),
+                                tr("Failed to create memory card '%1'").arg(card_path));
+      }
+    }
+  }
+
   if (!m_memory_card_editor_dialog)
   {
     m_memory_card_editor_dialog = new MemoryCardEditorDialog(this);
diff --git a/src/duckstation-qt/memorycardeditordialog.cpp b/src/duckstation-qt/memorycardeditordialog.cpp
index 5855cd2ed..a09cf23cd 100644
--- a/src/duckstation-qt/memorycardeditordialog.cpp
+++ b/src/duckstation-qt/memorycardeditordialog.cpp
@@ -44,9 +44,17 @@ MemoryCardEditorDialog::~MemoryCardEditorDialog() = default;
 
 bool MemoryCardEditorDialog::setCardA(const QString& path)
 {
-  const int index = m_ui.cardAPath->findData(QVariant(QDir::toNativeSeparators(path)));
+  int index = m_ui.cardAPath->findData(QVariant(QDir::toNativeSeparators(path)));
   if (index < 0)
-    return false;
+  {
+    QFileInfo file(path);
+    if (!file.exists())
+      return false;
+
+    QSignalBlocker sb(m_card_a.path_cb);
+    m_card_a.path_cb->addItem(file.baseName(), QVariant(path));
+    index = m_card_a.path_cb->count() - 1;
+  }
 
   m_ui.cardAPath->setCurrentIndex(index);
   return true;
@@ -54,14 +62,30 @@ bool MemoryCardEditorDialog::setCardA(const QString& path)
 
 bool MemoryCardEditorDialog::setCardB(const QString& path)
 {
-  const int index = m_ui.cardBPath->findData(QVariant(QDir::toNativeSeparators(path)));
+  int index = m_ui.cardBPath->findData(QVariant(QDir::toNativeSeparators(path)));
   if (index < 0)
-    return false;
+  {
+    QFileInfo file(path);
+    if (!file.exists())
+      return false;
+
+    QSignalBlocker sb(m_card_b.path_cb);
+    m_card_b.path_cb->addItem(file.baseName(), QVariant(path));
+    index = m_card_b.path_cb->count() - 1;
+  }
 
   m_ui.cardBPath->setCurrentIndex(index);
   return true;
 }
 
+bool MemoryCardEditorDialog::createMemoryCard(const QString& path)
+{
+  MemoryCardImage::DataArray data;
+  MemoryCardImage::Format(&data);
+
+  return MemoryCardImage::SaveToFile(data, path.toUtf8().constData());
+}
+
 void MemoryCardEditorDialog::resizeEvent(QResizeEvent* ev)
 {
   QtUtils::ResizeColumnsForTableView(m_card_a.table, {32, -1, 155, 45});
diff --git a/src/duckstation-qt/memorycardeditordialog.h b/src/duckstation-qt/memorycardeditordialog.h
index 1cb0fdb84..e18f69d9d 100644
--- a/src/duckstation-qt/memorycardeditordialog.h
+++ b/src/duckstation-qt/memorycardeditordialog.h
@@ -18,6 +18,8 @@ public:
   bool setCardA(const QString& path);
   bool setCardB(const QString& path);
 
+  static bool createMemoryCard(const QString& path);
+
 protected:
   void resizeEvent(QResizeEvent* ev);
   void closeEvent(QCloseEvent* ev);