diff --git a/src/frontend-common/common_host_interface.cpp b/src/frontend-common/common_host_interface.cpp
index 0923db00b..c55d1662e 100644
--- a/src/frontend-common/common_host_interface.cpp
+++ b/src/frontend-common/common_host_interface.cpp
@@ -424,9 +424,20 @@ bool CommonHostInterface::HandleHostKeyEvent(HostKeyCode key, bool pressed)
   return true;
 }
 
+bool CommonHostInterface::HandleHostMouseEvent(HostMouseButton button, bool pressed)
+{
+  const auto iter = m_mouse_input_handlers.find(button);
+  if (iter == m_mouse_input_handlers.end())
+    return false;
+
+  iter->second(pressed);
+  return true;
+}
+
 void CommonHostInterface::UpdateInputMap(SettingsInterface& si)
 {
   m_keyboard_input_handlers.clear();
+  m_mouse_input_handlers.clear();
   if (m_controller_interface)
     m_controller_interface->ClearBindings();
 
@@ -601,6 +612,25 @@ bool CommonHostInterface::AddButtonToInputMap(const std::string& binding, const
     return true;
   }
 
+  if (device == "Mouse")
+  {
+    if (StringUtil::StartsWith(button, "Button"))
+    {
+      const std::optional<s32> button_index = StringUtil::FromChars<s32>(button.substr(6));
+      if (!button_index.has_value())
+      {
+        Log_WarningPrintf("Invalid button in mouse binding '%s'", binding.c_str());
+        return false;
+      }
+
+      m_mouse_input_handlers.emplace(static_cast<HostMouseButton>(button_index.value()), std::move(handler));
+      return true;
+    }
+
+    Log_WarningPrintf("Malformed mouse binding '%s'", binding.c_str());
+    return false;
+  }
+
   if (StringUtil::StartsWith(device, "Controller"))
   {
     if (!m_controller_interface)
diff --git a/src/frontend-common/common_host_interface.h b/src/frontend-common/common_host_interface.h
index 4ff21b943..1d72d5f4d 100644
--- a/src/frontend-common/common_host_interface.h
+++ b/src/frontend-common/common_host_interface.h
@@ -23,6 +23,7 @@ public:
   friend ControllerInterface;
 
   using HostKeyCode = s32;
+  using HostMouseButton = s32;
 
   using InputButtonHandler = std::function<void(bool)>;
   using InputAxisHandler = std::function<void(float)>;
@@ -102,6 +103,7 @@ protected:
 
   void RegisterHotkey(String category, String name, String display_name, InputButtonHandler handler);
   bool HandleHostKeyEvent(HostKeyCode code, bool pressed);
+  bool HandleHostMouseEvent(HostMouseButton button, bool pressed);
   void UpdateInputMap(SettingsInterface& si);
 
   void AddControllerRumble(u32 controller_index, u32 num_motors, ControllerRumbleCallback callback);
@@ -124,6 +126,7 @@ private:
 
   // input key maps
   std::map<HostKeyCode, InputButtonHandler> m_keyboard_input_handlers;
+  std::map<HostMouseButton, InputButtonHandler> m_mouse_input_handlers;
 
   // controller vibration motors/rumble
   struct ControllerRumbleState