diff --git a/CMakeLists.txt b/CMakeLists.txt
index 9b8384ff9..3be9ff5b6 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -36,8 +36,9 @@ option(GL "Set to ON if targeting Desktop OpenGL" ${GL})
 option(GLES "Set to ON if targeting OpenGL ES" ${GLES})
 option(APPIMAGE_BUILD "Set to ON when building as an AppImage" ${APPIMAGE_BUILD})
 option(FLATPAK_BUILD "Set to ON when building as a Flatpak" ${FLATPAK_BUILD})
-option(STEAM_DECK "Set to ON to enable Valve Steam Deck specific build" ${STEAM_DECK})
-option(RPI "Set to ON to enable Raspberry Pi specific build" ${RPI})
+option(STEAM_DECK "Set to ON to enable a Valve Steam Deck specific build" ${STEAM_DECK})
+option(RETRODECK "Set to ON to enable a RetroDECK specific build" ${RETRODECK})
+option(RPI "Set to ON to enable a Raspberry Pi specific build" ${RPI})
 option(BUNDLED_CERTS "Set to ON to use bundled TLS/SSL certificates" ${BUNDLED_CERTS})
 option(CEC "Set to ON to enable CEC" ${CEC})
 option(VIDEO_HW_DECODING "Set to ON to enable FFmpeg HW decoding" ${VIDEO_HW_DECODING})
@@ -306,11 +307,20 @@ if(FLATPAK_BUILD)
     message("-- Building as a Flatpak")
 endif()
 
+if(STEAM_DECK AND RETRODECK)
+    message(FATAL_ERROR "-- STEAM_DECK and RETRODECK can't be combined")
+endif()
+
 if(STEAM_DECK)
     add_compile_definitions(STEAM_DECK)
     message("-- Building for the Valve Steam Deck")
 endif()
 
+if(RETRODECK)
+    add_compile_definitions(RETRODECK)
+    message("-- Building for RetroDECK")
+endif()
+
 if(RPI)
     add_compile_definitions(RASPBERRY_PI)
 endif()